Inspect a protein prediction against its evidence.
Search a gene, select a missense variant, and compare its AlphaMissense result with clinical classifications, structural confidence, and available laboratory measurements.
Indexed proteins open immediately. Other supported genes are analyzed and saved.
Four records, one variant.
Each source describes a different part of the same amino acid change. Ground Truth matches them by gene, residue position, and substitution before placing them together.
The result is not a single replacement score. It is a compact evidence trail where the model output, clinical classification, structural context, and experimental data can be read separately.
Structural context
A predicted 3D model and confidence score for each residue.
AlphaFold DBVariant prediction
A score and classification for each possible missense change.
AlphaMissenseClinical classification
A reviewed interpretation for variants with suitable clinical evidence.
ClinVar and CFTR2Lab measurement
An experimental measurement when a matched dataset is available.
MAVEdb
Gene, residue, and amino acid change provide the shared key.
Start with a studied protein.
These five proteins anchor the initial comparison. They are featured examples, not a limit on the explorer. Search above to open an indexed gene or analyze another supported gene.
Agreement is only the first reading.
A matching classification tells you that two records agree. It does not explain the structure around the residue or provide an independent experimental check.
AlphaFold confidence describes confidence in the predicted shape, not certainty about disease. Ground Truth keeps those meanings separate and shows patterns only within the data available for each protein.
HBB E7V
See every source attached to one change.
HBB E7V replaces glutamic acid with valine in beta globin. The linked report places its prediction, clinical classification, structural confidence, and source trail together.
Inspect HBB E7V- AlphaMissense
- Likely benign score 0.223
- Clinical classification
- pathogenic ClinVar
About Mehar
Mehar Minhas is a student researcher and science writer interested in making biological evidence easier to inspect and understand.
Ground Truth brings those interests into one interface. Readers can move from a protein-level summary to the records used for each comparison.
Choose the next record to inspect.
Open a featured protein, search another supported gene, or review how the records are matched.